Manchester United held Sevilla to a goalless draw in the first leg at the Ramon Sanchez Pizjuan Stadium last month.
Jose Mourinho had David De Gea to thank for the game ending in stalemate as the Spanish goalkeeper pulled off a number of world-class saves.
United are favourites to progress but Mourinho is expecting another tricky clash.
Speaking at his pre-match press conference, he said: “I think tomorrow is a very difficult match.
“I think we’re playing against a team that didn’t lose against Liverpool home and away – scored goals in Liverpool and drew the match in Liverpool and when I say Liverpool, it’s an example of a very good team and an example of an important stadium with big tradition.
“When I say Liverpool, it is just to say that Sevilla is a really good team and the result of the first leg is a result that leaves everything open for tomorrow.
“I don’t feel that we have any advantage in this moment.
“We are going to try to prove that we are better [than the first leg] and to try to win the match tomorrow.”
Sevilla head coach Vincenzo Montella said: “It’s a special match because we can reach the quarter-finals.
“It is special for me and for the club because it has been 60 years that the team has not been able to play in that round.
“We need to score one goal, and at home, we had the opportunities.
“It’s going to be tough, but we have confidence.”
When is Manchester United vs Sevilla?
Manchester United face Sevilla at 7.45pm.
Where is Manchester United vs Sevilla being played?
The match will be played at Old Trafford in Manchester.
Can you watch Manchester United vs Sevilla live?
Yes, you can.
Manchester United vs Sevilla is being shown live on BT Sport 2 (Sky 414, Sky HD 433, BT TV 409, Virgin Media 532), with the pre-match build-up starting at 7pm.
BT Sport will also be showing the match on a desktop computer or laptop via the company’s own site.
The BT Sport enhanced video player is also available online.
However EE mobile customers will be able to stream the game for free, thanks to a free subscription plan recently announced by the network.
“To say thanks for being with us, here’s a special sporting treat for our pay monthly mobile and tablet customers: three months’ free BT Sport on your EE phone and connected tablet,” BT explains.
“Just text SPORT to 150, register for a BT ID then download the BT Sport app and get watching!”
“Loads of the UK’s best sporting action, on the UK’s fastest network.”
You can visit the EE website for more information on the BT Sports offer.
Man Utd vs Sevilla: Scott McTominay in action during the first leg
Manchester United vs Sevilla team news
Paul Pogba is a doubt after missing Saturday’s 2-1 Premier League win against Liverpool.
Anthony Martial could return following a two-game absence while Michael Carrick could be included.
Phil Jones, Marcos Rojo, Daley Blind, Ander Herrera and Zlatan Ibrahimovic are all unavailable.
Sevilla will be missing defender Sebastien Corchia while Daniel Carrico is a doubt.
Ex-Manchester City winger Jesus Navas is unlikely to feature.
Former Manchester City winger Jesus Navas
Man Utd vs Sevilla: Jose Mourinho at his pre-match press conference
Manchester United vs Sevilla odds
Manchester United 8/13